Zhenglong Yuan
Papers
1
Total Citations
61
H-Index
1
About
Zhenglong Yuan is a pioneering figure in the development of antibody microarray technology for functional proteomics. His key research areas include protein-protein interactions, post-translational modifications (PTMs), and high-throughput protein profiling in mammalian cells. Yuan’s most influential work, "Antibodies Immobilized as Arrays to Profile Protein Post-translational Modifications in Mammalian Cells" (2004, 61 citations), introduced a groundbreaking approach that enabled the simultaneous detection of multiple PTMs—such as phosphorylation, acetylation, and ubiquitination—directly from complex cellular lysates. This innovation transformed how researchers study signaling networks and disease mechanisms, offering a scalable alternative to traditional Western blotting. By demonstrating that antibodies printed on solid supports could reliably capture modified proteins, Yuan provided a versatile platform for mapping the dynamic proteome. His contributions have been instrumental in advancing systems biology and biomarker discovery, earning recognition among peers for bridging antibody engineering with high-content analysis. For students and researchers, Yuan’s work exemplifies how clever assay design can unlock new dimensions of cellular regulation, making his antibody array a lasting tool in the molecular biologist’s arsenal.
Research Focus
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Top Papers
- 1