Yingjie Guan
Papers
1
Total Citations
61
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1
About
Yingjie Guan is a pioneering researcher in the fields of proteomics and cellular biochemistry, with a focus on protein post-translational modifications (PTMs) and antibody-based detection technologies. Their groundbreaking work, most notably the 2004 study "Antibodies Immobilized as Arrays to Profile Protein Post-translational Modifications in Mammalian Cells" (61 citations), introduced a novel antibody array system that revolutionized the study of PTMs. By printing antibodies on solid supports, Guan developed a high-throughput method to simultaneously detect multiple modified proteins in mammalian cells, enabling researchers to map complex signaling networks and disease-related pathways. This innovation built on earlier work demonstrating antibody arrays for protein-protein interactions, establishing Guan as a key contributor to the evolution of functional proteomics tools. Their approach has been widely adopted for profiling phosphorylation, acetylation, and other modifications, impacting fields from cancer biology to drug discovery. Guan’s work exemplifies how creative assay design can transform our ability to analyze dynamic cellular processes, offering students and researchers a powerful lens into the molecular underpinnings of health and disease.
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Top Papers
- 1