Sundeep Shah
Papers
1
Total Citations
160
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1
About
Sundeep Shah is a pioneer in the development of high-throughput screening technologies for drug discovery, with a primary focus on protein kinases and phosphatases—key regulators of cell proliferation, apoptosis, and metabolism. His landmark 2002 paper, "A FRET-Based Assay Platform for Ultra-High Density Drug Screening of Protein Kinases and Phosphatases," has garnered over 160 citations, establishing a foundational methodology that enables rapid, sensitive detection of enzymatic activity in complex biological systems. This work revolutionized the ability to screen millions of compounds efficiently, accelerating the identification of potential therapeutics for diseases driven by aberrant phosphorylation, such as cancer and metabolic disorders. Shah’s contributions bridge biochemistry and translational medicine, providing researchers with robust tools to explore signal transduction pathways. His assay platform remains a gold standard in the field, cited extensively for its impact on both basic research and pharmaceutical development. By addressing the critical need for scalable, reliable screening methods, Shah has empowered a generation of scientists to interrogate kinase and phosphatase biology with unprecedented precision, cementing his legacy as a key innovator in chemical biology and drug discovery.
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