R. Frakulli

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About

R. Frakulli has established himself as a leading voice in the application of stereotactic body radiotherapy (SBRT) for challenging gastrointestinal malignancies, with a particular focus on pancreatic cancer. His most-cited work, a 2018 systematic review on pain relief following SBRT for locally advanced pancreatic carcinoma (LAPC), has garnered 64 citations and remains a cornerstone reference for clinicians managing this difficult disease. The review synthesized evidence demonstrating that SBRT not only offers a non-invasive option for local tumor control but also provides significant and durable palliation of cancer-related pain—a critical endpoint for patients with poor prognosis. Beyond this landmark paper, Frakulli’s broader research portfolio explores the optimization of SBRT fractionation schemes and the integration of advanced imaging for target delineation in pancreatic and other abdominal tumors. His contributions have helped shift the paradigm from purely palliative intent toward more aggressive, yet tolerable, local therapies that improve quality of life. Through his systematic reviews and clinical studies, Frakulli continues to shape evidence-based guidelines for stereotactic radiotherapy, making him a respected figure in radiation oncology and a valuable resource for researchers seeking to improve outcomes in LAPC.