Norbert Pfeiffer

Papers

Total Citations

204

H-Index

About

Norbert Pfeiffer is a leading figure in ophthalmology whose research has significantly advanced the understanding and diagnosis of ocular surface diseases, particularly dry eye syndrome. His work is distinguished by pioneering the application of proteomic technologies to ophthalmology. Pfeiffer’s most cited study, “SELDI-TOF-MS ProteinChip Array Profiling of Tears from Patients with Dry Eye” (2005, 204 citations), was a landmark contribution that demonstrated the feasibility of using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to analyze tear fluid. This work revealed distinct protein and peptide profiles in dry eye patients, establishing a foundation for biomarker discovery and non-invasive diagnostics. By moving beyond traditional electrophoretic methods, Pfeiffer opened a new avenue for molecular characterization of ocular surface conditions. His research has had a lasting impact, providing a methodological framework that continues to influence studies on tear film composition and disease pathology. Through this innovative approach, Pfeiffer has not only deepened the mechanistic understanding of dry eye but also paved the way for more precise, personalized diagnostic tools in ophthalmology.