Mary Simonian
Papers
1
Total Citations
14
H-Index
1
About
Dr. Mary Simonian is a leading dental researcher whose work illuminates the complex biological responses of the dental pulp to bacterial invasion. Her primary research areas center on pulp biology, neuro-immune interactions, and the cellular mechanisms underlying dentin repair. In her most-cited study, "Adaptive Calcified Matrix Response of Dental Pulp to Bacterial Invasion Is Associated with Establishment of a Network of Glial Fibrillary Acidic Protein+/Glutamine Synthetase+ Cells" (2010, 14 citations), Simonian made a pivotal contribution by identifying a previously unrecognized network of glial-like cells expressing GFAP and glutamine synthetase that forms in response to bacterial challenge. This discovery reshaped understanding of how the pulp orchestrates its defensive calcified matrix response, linking glial cell activity to the adaptive mineralization process. While her citation count reflects the niche but critical nature of her work, Simonian’s findings have profound implications for regenerative endodontics and the development of therapies to preserve pulp vitality. Her research bridges basic neurobiology and clinical dentistry, offering new targets for managing deep caries and pulpal inflammation.
Research Focus
Key Achievements
Top Papers
- 1