Mark C. Willingham
Papers
1
Total Citations
26
H-Index
1
About
Mark C. Willingham has made significant contributions to proteomics and stress biology, with a particular focus on the model organism *Schizosaccharomyces pombe*. His key research areas include quantitative proteomics, oxidative stress responses, and the development of automated analytical platforms. Willingham's most notable work pioneered the integration of two-dimensional difference gel electrophoresis (2D-DIGE) with mass spectrometry and a novel robotics platform, enabling high-throughput identification of stress-induced proteomic changes. His landmark 2005 study, which has accumulated 26 citations, systematically mapped the proteomic alterations in *S. pombe* under oxidative stress conditions, demonstrating how robotic and manual methods can be synergistically applied to track differentially expressed proteins. This work established a methodological framework that advanced the field's understanding of cellular stress responses at the protein level. Willingham's contributions are particularly valuable for researchers studying environmental stress adaptation and for those developing automated proteomic workflows. His integrated approach continues to influence modern proteomics, showcasing how technological innovation can drive biological discovery in stress signaling pathways.
Research Focus
Key Achievements
Top Papers
- 1