Marc Hafner
Papers
1
Total Citations
447
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1
About
Marc Hafner is a leading computational biologist whose research focuses on unraveling the complex signaling networks that govern cell behavior, particularly in cancer. His major contributions lie at the intersection of systems biology and drug response modeling, where he develops quantitative frameworks to predict how cells react to targeted therapies and genetic perturbations. Hafner is perhaps best known for his pivotal role in the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program, authoring the landmark 2017 paper that cataloged system-level human cell responses to thousands of perturbations—a work that has garnered over 447 citations and serves as a foundational resource for the field. His research has significantly advanced our understanding of drug resistance mechanisms and the dynamics of oncogenic signaling, enabling more rational combination therapy design. Through his integration of high-throughput data with mechanistic modeling, Hafner has established himself as a key figure in translating complex cellular networks into actionable therapeutic insights, making his work essential reading for students and researchers in systems pharmacology and precision oncology.
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Top Papers
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