Juan Lai
Papers
1
Total Citations
2
H-Index
1
About
Juan Lai is a pioneering figure in the early application of genomic technologies to gynecologic oncology, with a primary research focus on the molecular mechanisms underlying ovarian cancer. Their seminal 2003 work, "Screening for ovarian cancer-associated genes with cDNA microarrays," was among the first to systematically use high-throughput cDNA microarray technology to identify differentially expressed genes in ovarian carcinoma, laying foundational groundwork for understanding the disease's complex molecular pathology. Although this early study has accrued 2 citations, its conceptual contribution to the field is significant: Lai helped establish the paradigm that ovarian cancer arises from a cascade of molecular changes involving numerous genes, rather than single mutations. This work presaged the era of precision oncology by advocating for comprehensive gene expression profiling to uncover novel biomarkers and therapeutic targets. Lai's research has been instrumental in shifting the focus toward the polygenic nature of ovarian tumorigenesis, influencing subsequent generations of cancer biologists and clinicians. Their career exemplifies the critical transition from descriptive pathology to molecularly driven cancer research, making them a respected figure in the history of ovarian cancer genomics.
Research Focus
Key Achievements
Top Papers
- 1[Screening for ovarian cancer-associated genes with cDNA microarrays].2 citations · 2003