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About

Jonathan Melamed is a leading researcher in prostate cancer pathology and imaging, whose work bridges the gap between radiology, histology, and surgical oncology. His primary research areas include multi-modal image co-registration, tissue biobanking, and the application of artificial intelligence to real-time surgical pathology. Melamed’s major contributions center on developing a platform for 3D co-registration of in-vivo MRI, ex-vivo MRI, and whole-mount pathology—a foundational tool that has enabled precise spatial correlation of imaging findings with histologic cancer foci, earning 21 citations. He also played a key role in establishing the Prostate Cancer Biorepository Network, creating standardized protocols for high-quality, well-annotated tissue derivatives from radical prostatectomy specimens, a resource cited 16 times for its impact on translational research. Most notably, in 2025, Melamed co-authored a landmark study demonstrating that stimulated Raman histology, combined with artificial intelligence, can provide near real-time interpretation of surgical margins during radical prostatectomy—a breakthrough with 9 citations that promises to improve intraoperative decision-making and reduce positive margin rates. His work consistently advances precision oncology by integrating cutting-edge imaging and computational tools into clinical practice.