Guohong Peng
Papers
1
Total Citations
37
H-Index
1
About
Guohong Peng is a structural biologist whose research centers on the molecular mechanisms of plant alkaloid biosynthesis, with a particular focus on enzymes that generate the vast chemical diversity of indole alkaloids. His most-cited work, a 2004 study on strictosidine glucosidase, provided the first detailed structural insights into this pivotal enzyme, which initiates the biosynthetic pathways leading to thousands of unique alkaloid skeletons—including many with pharmaceutical relevance. By successfully expressing, purifying, and crystallizing the enzyme, and performing preliminary X-ray analysis, Peng laid the groundwork for understanding how nature constructs complex bioactive molecules from simple precursors. This foundational study has garnered 37 citations, reflecting its importance in the fields of plant biochemistry and natural product enzymology. Peng’s contributions have helped illuminate the structural logic behind alkaloid diversity, offering a platform for future engineering of these pathways for drug discovery and synthetic biology applications.
Research Focus
Key Achievements
Top Papers
- 1