Gerlinde Grelle
Papers
1
Total Citations
59
H-Index
1
About
Gerlinde Grelle has made significant contributions to the field of proteomics, with a primary focus on elucidating protein-protein interactions that govern cellular regulation and disease mechanisms. Her most cited work, "Identification of VCP/p97, Carboxyl Terminus of Hsp70-interacting Protein (CHIP), and Amphiphysin II Interaction Partners Using Membrane-based Human Proteome Arrays" (2005, 59 citations), showcases her pioneering approach to systematically mapping interaction networks. By employing membrane-based human proteome arrays, Grelle identified novel binding partners for key proteins involved in protein quality control and endocytosis, including VCP/p97, CHIP, and amphiphysin II. This work provided critical insights into how these proteins coordinate cellular processes such as protein degradation and membrane trafficking. Her research has been instrumental in advancing our understanding of the complex regulatory networks underlying cellular homeostasis, with implications for neurodegenerative diseases and cancer. Grelle’s innovative use of high-throughput proteomic techniques continues to influence the field, offering a powerful framework for future studies on protein function and therapeutic target discovery.
Research Focus
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Top Papers
- 1