The role of ROSA navigated intracranial electrode implantation technique on precise epileptogenic zone localization

Abstract

To evaluate the role of ROSA (Robotized Stereotactic Assistant) navigated intracranial electrode implantation on precise epileptogenic zone localization, 40 patients with drug-resistant epilepsy between March 2012 and September 2013 underwent the procedure. Demographics, noninvasive clinical data, complications and seizure-control outcome after resection were retrospectively collected and analyzed. Of the 40 patients surveyed, 29 underwent unilateral implantation, 11 underwent bilateral implantation. 1 patient experienced an intracranial hematoma caused by the implantation, while the remaining patients underwent the prolonged video-EEG (VEEG) monitoring with no complications. Electrodes were preserved, on average, for 11.4 days ( range 4-34 days); Observed clinical seizures, on average, were 9.9 times per patient (range 2-38 times); There were no cerebrospinal fluid leak, Intracranial hematoma, electrodes fracture or patient death, except 1 patient scalp infection (2.6%, scalp infection rate); 37 patients’ seizure onset area was precisely localized; 32 patients underwent stereo-electroencephalography or coagulation (SEEG)-guide resection or coagulation and were followed up for more than 6 months.