Intelligent Chemical Synthesis in an Undergraduate Teaching Laboratory: Continuous Flow Synthesis of S_NAr Reaction with Automated Robot-Assisted Condition Screening

Abstract

An integrated undergraduate teaching laboratory experiment was developed by applying an automated robot, a 48-well plate, and continuous flow chemistry in a typical SNAr reaction. This experiment involved the concepts of green chemistry, homogeneous reaction, continuous flow chemistry and intelligent chemistry, encouraging students to determine the optimal flow synthesis conditions independently. By engaging in this experiment, students gain hands-on experience with modern chemical engineering practices and learn to appreciate the efficiency and sustainability of continuous flow processes.