Deep Brain Stimulation on Ca2+ Signalling and Neuro-Glial Network: A Digital Implementation

Abstract

the anomalously accumulation of Amyloid beta ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{A}\beta$ </tex-math></inline-formula> ) peptides within neuroglial network can originate the dyshomeostasis of intracellular calcium waves (ICWs) and result the evolution of neuropsychiatric disorders. The hardware implementation of the biologically plausible neuron and glial cell models may assist to reveal accurately to the diagnostic and treatment approaches of the neurological disorders. Thus, this paper presents a low-cost hardware approach according to coordinate rotation digital computer (CORDIC) method for a deep brain stimulator to investigate the therapeutic conditions for neuropathological states of Alzheimer’s disease (AD). As a proof of concept, a FPGA implementation is performed on the modified biologically plausible components of the proposed stimulator. The results of physical implementation and the numerical analysis illustrate that, the proposed bio-inspired brain stimulator design can assist the transition of the aberrant ICW patterns into the normal biochemical circumstances. As a result, the proposed deep brain stimulation strategy based on the modified models can be a good candidate for the further development of bio-robotics systems and rehabilitation therapy of AD at early stages.