Clear cell renal cell carcinoma with osseous metaplasia: a case report.

Abstract

INTRODUCTION: Osseous metaplasia is a rare histologic feature not often associated with renal cell carcinoma; there are only 14 reported cases and just four associated with the clear cell variant. We report the case of a 48-year-old female who presented with diffuse abdominal pain. MATERIALS AND METHODS: We reviewed the case of woman who underwent a robotic assisted partial nephrectomy for an enhancing renal mass. Histologic analyses and immunostains were reviewed by multiple pathologists. RESULTS: CT imaging revealed a 1.8 cm irregular enhancing exophytic mass with calcifications. The patient subsequently underwent robotic assisted laparoscopic partial nephrectomy. The final pathologic diagnosis was clear cell carcinoma with metaplastic bone formation. CONCLUSION: While the prognostic significance of bone metaplasia occurrence in renal cell carcinoma is controversial, such that can safely be managed with partial nephrectomy.