Pharmacology

Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data

Alexander Aliper, Sergey Plis, Artem V. Artemov, Alvaro Ulloa, Polina Mamoshina, Alex Zhavoronkov

引用数: 600 • 2016

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Anna Herland, Ben M. Maoz, Debarun Das, Mahadevabharath R. Somayaji, Rachelle Prantil‐Baun, Richard Novák, Michael J. Cronce, Tessa Huffstater, Sauveur S. F. Jeanty, Angeliki Chalkiadaki, David B. Chou, Susan Marquez, Aaron Delahanty, Sasan Jalili‐Firoozinezhad, Yuka Milton, Alexandra Sontheimer-Phelps, Ben Swenor, Oren Levy, Kevin Kit Parker, Andrzej Przekwas, Donald E. Ingber

引用数: 463 • 2020

Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests

Paweł Szymański, Magdalena Markowicz-Piasecka, Elżbieta Mikiciuk‐Olasik

引用数: 439 • 2011

Enzyme-powered Janus platelet cell robots for active and targeted drug delivery

Songsong Tang, Fangyu Zhang, Hua Gong, Fanan Wei, Jia Zhuang, Emil Karshalev, Berta Esteban‐Fernández de Ávila, Chuying Huang, Zhidong Zhou, Zhengxing Li, Lu Yin, Haifeng Dong, Ronnie H. Fang, Xueji Zhang, Liangfang Zhang, Joseph Wang

引用数: 413 • 2020

Plant natural products: Back to the future or into extinction?

James D. McChesney, Sylesh K. Venkataraman, John T. Henri

引用数: 376 • 2007

Determination of the Role of the Human RNase H1 in the Pharmacology of DNA-like Antisense Drugs

Hongjiang Wu, Walt F. Lima, Hong Zhang, Amy C. Fan, Hong Sun, Stanley T. Crooke

引用数: 350 • 2004

Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner

Itsaso García‐Arcos, Patrick Geraghty, Nathalie Baumlin, Michael Campos, Abdoulaye Dabo, Bakr Jundi, Neville Cummins, Edward Eden, Astrid Grosche, Matthias Salathé, Robert Foronjy

引用数: 343 • 2016

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

Iain D. Kerr, Ji Hae Lee, Christopher J. Farady, Rachael Marion, Mathias Rickert, Mohammed Sajid, Kailash C. Pandey, Conor R. Caffrey, Jennifer Legac, Elizabeth Hansell, James H. McKerrow, Charles S. Craik, Philip Rosenthal, Linda S. Brinen

引用数: 296 • 2009

Zebrafish embryos and larvae: A new generation of disease models and drug screens

Shaukat Ali, Danielle L. Champagne, Herman P. Spaink, Michael K. Richardson

引用数: 253 • 2011

The fluorometric microculture cytotoxicity assay

Elin Lindhagen, Peter Nygren, Rolf Larsson

引用数: 236 • 2008

Virtual Screening in Drug Discovery

Juan Alvarez, Brian K. Shoichet

引用数: 234 • 2005

Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood–brain barrier in vitro

Helmut Franke, Hans‐Joachim Galla, Carsten T. Beuckmann

引用数: 228 • 2000

Metabolic Stability for Drug Discovery and Development

Collen Masimirembwa, Ulf Bredberg, Tommy B. Andersson

引用数: 219 • 2003

Two approaches to discovering and developing new drugs for Chagas disease

McKerrow Jh, PS Doyle, Engel Jc, LM Podust, Sheilah A. Robertson, Rafaela Salgado Ferreira, T Saxton, Michelle R. Arkin, ID Kerr, LS Brinen, CS Craik

引用数: 173 • 2009

Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases

Kevin Williams, Elizabeth Bilsland, Andrew C. Sparkes, Wayne Aubrey, Michael J. Young, Larisa Soldatova, Kurt De Grave, Jan Ramon, Michaela de Clare, Worachart Sirawaraporn, Stephen G. Oliver, Ross D. King

引用数: 161 • 2015

Therapeutic drug monitoring and LC–MS/MS

Jo Adaway, Brian Keevil

引用数: 157 • 2011

Performance-Based Exposure Control Limits for Pharmaceutical Active Ingredients

Bruce D. Naumann, Edward V. Sargent, Barry S. Starkman, William J. Fraser, Gail T. Becker, G. David Kirk

引用数: 151 • 1996

Rare diseases and orphan drugs

J K Aronson

引用数: 146 • 2006

Optimization of a Higher Throughput Microsomal Stability Screening Assay for Profiling Drug Discovery Candidates

Li Di, Edward H. Kerns, Yan Hong, Teresa Kleintop, Oliver J. McConnell, Donna M. Huryn

引用数: 137 • 2003

An Experimental Framework for Quantifying Bacterial Tolerance

Asher Brauner, Noam Shoresh, Ofer Fridman, Nathalie Q. Balaban

引用数: 126 • 2017