Drug metabolism

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Anna Herland, Ben M. Maoz, Debarun Das, Mahadevabharath R. Somayaji, Rachelle Prantil‐Baun, Richard Novák, Michael J. Cronce, Tessa Huffstater, Sauveur S. F. Jeanty, Angeliki Chalkiadaki, David B. Chou, Susan Marquez, Aaron Delahanty, Sasan Jalili‐Firoozinezhad, Yuka Milton, Alexandra Sontheimer-Phelps, Ben Swenor, Oren Levy, Kevin Kit Parker, Andrzej Przekwas, Donald E. Ingber

引用数: 463 • 2020

Metabolic Stability for Drug Discovery and Development

Collen Masimirembwa, Ulf Bredberg, Tommy B. Andersson

引用数: 219 • 2003

An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion

Colleen A. McNaney, Dieter M. Drexler, Serhiy Hnatyshyn, Tatyana Zvyaga, Jay O. Knipe, James V. Belcastro, Mark Sanders

引用数: 134 • 2008

Analysis of Live Single Cells by Confocal Microscopy and High-Resolution Mass Spectrometry to Study Drug Uptake, Metabolism, and Drug-Induced Phospholipidosis

Liliana Pedro, Patrick J. Rudewicz

引用数: 15 • 2020

An Automated Method of Mass Drug Testing Applied to Screening for Antimalarial Activity

Richard J. Cenedella, L.H. Saxe, Knox Van Dyke

引用数: 12 • 2009

[Perhexilline maleate: relationship between side-effects, plasma concentrations and rate of metabolism (author's transl)].

E Singlas, Goujet Ma, Peter F. W. Simon

引用数: 4 • 1978

Chapter 5 In vitro dmpk screening in drug discovery, role of lc-ms/ms

Inhou Chu, Amin A. Nomeir

引用数: 3 • 2005