Zorik Chilingaryan
Papers
1
Total Citations
62
H-Index
1
About
Zorik Chilingaryan is a structural biologist whose work has significantly advanced fragment-based drug discovery (FBDD) and protein crystallography. His research focuses on developing and refining screening methodologies that enable the identification of low-molecular-weight compounds as starting points for novel therapeutics. His highly cited 2012 review, "Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls" (62 citations), provides a critical analysis of the field, detailing both the transformative potential and the technical challenges of using X-ray crystallography for fragment screening. This work has served as a key reference for researchers navigating the complexities of FBDD, from hit validation to avoiding common artifacts. Beyond this landmark paper, Chilingaryan’s contributions have helped establish best practices for integrating structural data into early-stage drug discovery pipelines. His insights into the pitfalls of crystallographic screening have been instrumental in improving the reliability and reproducibility of fragment-based approaches, making his research essential reading for any scientist working at the interface of structural biology and medicinal chemistry.
Research Focus
Key Achievements
Top Papers
- 1Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls62 citations · 2012