Zi-Wei Chen
Papers
1
Total Citations
80
H-Index
1
About
Zi-Wei Chen has made pioneering contributions to structural neurobiology and proteomics, with a particular focus on the mass spectrometric analysis of low-abundance integral membrane proteins. Chen’s most-cited work, “Deep Amino Acid Sequencing of Native Brain GABAA Receptors Using High-Resolution Mass Spectrometry” (2011, 80 citations), addressed the formidable technical challenges of sequencing transmembrane domains—from solubilization and purification to enzymatic digestion and peptide extraction. By developing robust protocols for these complex steps, Chen enabled the first deep sequencing of native GABAA receptors, which are critical targets for neurological drugs and disorders. This achievement not only advanced our understanding of receptor architecture but also established a methodological framework for studying other recalcitrant membrane proteins. Chen’s research sits at the intersection of analytical chemistry and neuroscience, providing tools that have empowered subsequent studies on neurotransmitter receptor function and pharmacology. The impact of this work is reflected in its continued citation by researchers tackling similar proteomic challenges, cementing Chen’s reputation as a key innovator in high-resolution mass spectrometry applied to neurobiology.
Research Focus
Key Achievements
Top Papers
- 1