Yuan‐Ping Pang
Papers
1
Total Citations
25
H-Index
1
About
Yuan‐Ping Pang is a computational chemist and pharmacologist whose research focuses on the rational design of antidotes for organophosphate poisoning and the molecular mechanisms of acetylcholinesterase inhibition. His major contributions include the kinetic analysis of alkylene-linked bis-pyridiniumaldoximes, which are reactivators of human acetylcholinesterase inhibited by nerve agents and pesticides. By systematically characterizing how these oximes interact with inhibited enzyme variants, Pang has provided critical insights into the structural and kinetic factors that govern reactivation efficacy—work that has informed the development of more potent and broad-spectrum antidotes. His 2010 study on this topic, which has garnered 25 citations, exemplifies his approach of combining computational modeling with experimental validation to solve real-world toxicological problems. Beyond this, Pang is known for his pioneering use of molecular dynamics simulations to explore enzyme-inhibitor interactions, and his work has been instrumental in advancing the field of cholinesterase pharmacology. His research continues to bridge the gap between computational predictions and therapeutic applications, making him a key figure in the fight against chemical threats.
Research Focus
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Top Papers
- 1