Xiaochun Yu
Papers
1
Total Citations
235
H-Index
1
About
Xiaochun Yu is a leading molecular biologist whose pioneering work has fundamentally advanced our understanding of DNA damage repair and tumor suppression. His research primarily focuses on the molecular mechanisms of the DNA damage response, particularly the roles of the BRCA1 tumor suppressor and ubiquitin signaling in maintaining genomic stability. Yu’s landmark 2003 study, cited over 235 times, revealed the phosphopeptide binding specificities of BRCA1’s BRCT domains, demonstrating that these domains act as phospho-serine/threonine binding modules. This seminal discovery provided a critical mechanistic framework for how BRCA1 recognizes sites of DNA damage, explaining how mutations in these domains disrupt repair and cause breast and ovarian cancers. Beyond this, Yu has made major contributions to understanding how ubiquitination and deubiquitination regulate the DNA damage response, identifying key enzymes like OTUB1 and elucidating their roles in controlling repair pathway choice. His work has been widely recognized for its profound implications in cancer biology, shaping how researchers approach the study of genome maintenance and therapeutic targeting of DNA repair pathways.
Research Focus
Key Achievements
Top Papers
- 1Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains235 citations · 2003