William Burkitt
Papers
1
Total Citations
58
H-Index
1
About
William Burkitt is a leading figure in structural biochemistry and biophysics, whose work has fundamentally advanced the field of hydrogen/deuterium exchange mass spectrometry (HDX-MS). His most-cited contribution, a 2008 study on the "Assessment of the repeatability and reproducibility of hydrogen/deuterium exchange mass spectrometry measurements," established a critical framework for standardizing HDX-MS as a robust, quantitative tool. By constructing an automated system integrating an XYZ robotic autosampler with a 4.7 T Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer, Burkitt solved a major challenge in the field: ensuring consistent, high-resolution measurements of protein dynamics. This work, cited 58 times, provided the foundational methodology that enabled researchers to reliably probe protein conformation, folding, and interactions. Burkitt’s contributions have been instrumental in transforming HDX-MS from a specialized technique into a widely adopted platform for studying protein structure and function, with profound implications for drug discovery and understanding disease mechanisms. His dedication to reproducibility and automation continues to shape best practices in structural mass spectrometry.
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