William A. LaMarr
Papers
1
Total Citations
36
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About
William A. LaMarr is a pioneering figure in the development of high-throughput mass spectrometry for clinical diagnostics, with a particular focus on lysosomal storage disorders. His most-cited work, "Novel heparan sulfate assay by using automated high-throughput mass spectrometry: Application to monitoring and screening for mucopolysaccharidoses" (2014, 36 citations), revolutionized the detection of mucopolysaccharidoses by enabling rapid, automated quantification of heparan sulfate—a key biomarker. This breakthrough bridged the gap between complex analytical chemistry and practical newborn screening, offering a scalable solution for early diagnosis. LaMarr’s contributions extend beyond method development; his work has directly impacted clinical monitoring, allowing for more effective treatment management in patients. By integrating automation with mass spectrometry, he addressed critical bottlenecks in sample throughput and reproducibility, setting a new standard for biomarker assays. His research remains foundational for laboratories transitioning from manual to automated workflows, and his innovative approach continues to inspire advances in precision medicine for rare genetic diseases.
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