Vicent Pelechano

European Bioinformatics Institute, Karolinska Institutet

Papers

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About

Vicent Pelechano is a leading figure in functional genomics and chromatin biology, best known for pioneering high-throughput methods to decode the epigenome. His major contributions center on developing scalable, multiplexed chromatin profiling technologies. In his landmark 2015 work, "A high-throughput ChIP-Seq for large-scale chromatin studies" (31 citations), Pelechano introduced Bar-ChIP, a technique that directly ligates molecular barcodes to chromatin fragments, dramatically increasing experimental throughput. This innovation was further refined in his 2017 study, "Multiplexed ChIP-Seq Using Direct Nucleosome Barcoding" (8 citations), which streamlined the process for broader application. By enabling the concurrent analysis of multiple DNA-protein interactions, Pelechano’s methods have empowered researchers to map histone modifications and transcription factor binding at unprecedented scale, accelerating discoveries in gene regulation and disease biology. His work stands as a cornerstone for modern epigenomic studies, offering a practical, cost-effective solution for large-scale chromatin analysis. Pelechano’s contributions continue to shape the field, making him a key resource for students and researchers seeking to explore the dynamic landscape of chromatin regulation.