Papers
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Total Citations
31
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About
Tom Payne is a pioneering researcher in antibody engineering and membrane protein biology, with a focus on developing innovative tools for therapeutic discovery. His most cited work introduces a groundbreaking mammalian display system for selecting antibodies against membrane proteins in their native conformations—a notoriously challenging area due to the structural complexity and instability of these targets. This 2020 study, with 31 citations, addresses a critical bottleneck in biomedical research: the difficulty of generating reliable, specific antibodies that recognize membrane proteins as they exist on cell surfaces. By enabling the discovery of high-quality polyclonal and monoclonal antibodies, Payne's method has significant implications for drug development, diagnostics, and basic cell biology. His contributions stand out for their practical impact, offering a robust platform that bypasses traditional limitations in antibody generation. Payne's work is particularly notable for bridging the gap between protein engineering and translational medicine, providing researchers with a powerful tool to target previously inaccessible membrane proteins. His achievements underscore a commitment to advancing immunotechnology, making him a key figure in the quest for more effective biologics and a valuable resource for students and researchers exploring the frontiers of antibody discovery.
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