Thomas H. Keller
Papers
1
Total Citations
103
H-Index
1
About
Thomas H. Keller is a distinguished medicinal chemist whose research has centered on the development of antiviral therapeutics and the structural biology of emerging viral pathogens. His most influential work has targeted the Zika virus protease, a critical enzyme for viral replication, where he elucidated its potential as a viable drug target. This foundational study, published in 2017 and garnering over 100 citations, has guided subsequent efforts to design small-molecule inhibitors against Zika and related flaviviruses. Beyond this, Keller’s broader contributions include pioneering approaches to fragment-based drug discovery and the optimization of lead compounds for infectious diseases, often bridging academic insights with translational applications. His work has not only advanced the mechanistic understanding of viral proteases but also provided a strategic framework for rapid response to pandemic threats. With a career marked by high-impact publications and collaborative leadership in global health initiatives, Keller remains a key figure in antiviral drug development, inspiring researchers to tackle neglected and emerging viral diseases through rigorous chemical biology.
Research Focus
Key Achievements
Top Papers
- 1Zika Virus Protease: An Antiviral Drug Target103 citations · 2017