Tanya Pawson
Papers
1
Total Citations
80
H-Index
1
About
Tanya Pawson’s research centers on the structural biology of nuclear hormone receptors, with a particular focus on estrogen receptor (ER) signaling and its therapeutic modulation. Her most cited work, a 2007 study with 80 citations, provides critical structural insights into how antagonist-bound estrogen receptors recruit transcriptional corepressors—a mechanism that underpins the tissue-specific effects of widely used ER antagonists in breast cancer treatment. By solving crystal structures of affinity-selected peptides in complex with antagonist-bound ERα, Pawson elucidated the molecular basis for corepressor recognition, revealing how these interactions contribute to the selective modulation of gene expression. This foundational contribution has advanced our understanding of nuclear receptor pharmacology and informed the design of more targeted endocrine therapies. Pawson’s work bridges structural biology and translational medicine, offering a molecular roadmap for improving the efficacy and reducing the side effects of hormone-based cancer treatments. Her findings remain highly relevant for researchers exploring allosteric regulation, drug resistance, and the development of next-generation selective ER modulators and degraders.
Research Focus
Key Achievements
Top Papers
- 1