Sonia Nieto
Papers
1
Total Citations
122
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1
About
Sonia Nieto is a pioneering researcher in high-throughput chiral analysis and supramolecular chemistry, whose work has fundamentally advanced the rapid screening of enantiomeric purity—a critical challenge in pharmaceutical development. Her most cited study (2008, 122 citations) introduced an innovative protocol that simultaneously determines identity, enantiomeric excess (ee), and concentration of chiral 1,2-diamines by exploiting metal-to-ligand charge transfer (MLCT) transitions in circular dichroism (CD) spectroscopy. This breakthrough was the first to combine these three analytical parameters in a single, fast measurement, dramatically accelerating the screening process for asymmetric synthesis. Beyond this landmark paper, Nieto’s research has explored the design of chiral sensors and probes, leveraging the sensitivity of CD spectroscopy to detect subtle structural differences. Her contributions have been widely recognized for bridging the gap between fundamental coordination chemistry and practical high-throughput methodologies, enabling more efficient optimization of enantioselective reactions. For students and researchers, Nieto’s work exemplifies how creative application of spectroscopic principles can solve real-world problems in drug discovery and chemical manufacturing, making her a key figure in modern analytical chemistry.
Research Focus
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Top Papers
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