Papers
9
Total Citations
194
H-Index
7
About
Siyuan Lei is a radiation oncologist whose research has significantly advanced the field of stereotactic body radiation therapy (SBRT) for urological and intracranial cancers, with a particular focus on prostate cancer and meningiomas. Lei's most impactful contribution — garnering 59 citations — introduced an overlap-volume histogram-driven planning methodology that substantially improved robotic SBRT plan quality for organ-confined prostate cancer, refining how clinicians balance tumor coverage against normal tissue sparing. His work on PSA kinetics following robotic SBRT (25 citations) helped characterize post-treatment biochemical response patterns, providing clinicians with better prognostic benchmarks. Lei has also made meaningful strides in minimizing treatment-related toxicity, investigating strategies to reduce acute urinary morbidity through alpha-adrenergic antagonists and urethral dose reduction (24 citations), and analyzing rectal complications to inform clinical trial design. His research on IMRT combined with SBRT boost for unfavorable-risk prostate cancer offers a compelling, less invasive alternative to brachytherapy, with outcomes data spanning five years. Additional contributions include five-fraction radiosurgery for meningiomas and innovative use of iodinated rectal spacers during SBRT. Collectively, Lei's body of work reflects a sustained commitment to optimizing both the precision and tolerability of advanced radiotherapy techniques.
Research Focus
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Top Papers
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