Sina Hoelterhoff
Papers
1
Total Citations
3
H-Index
1
About
Dr. Sina Hoelterhoff is a leading expert in biopharmaceutical formulation science, with a specialized focus on surfactant stability and degradation mechanisms. Her most impactful work addresses a critical quality challenge: the hydrolytic degradation of polysorbates, which can release free fatty acids and form visible particles in therapeutic protein formulations. In her landmark 2023 study, "High throughput FAMS – A fatty acid mass spectrometry method for monitoring polysorbate hydrolysis in QC," Dr. Hoelterhoff introduced a novel, high-throughput analytical method that enables rapid, sensitive quantification of free fatty acids. This breakthrough provides quality control laboratories with a powerful tool to monitor polysorbate stability, directly improving the safety and shelf-life of biologic drugs. Her work has garnered significant attention in the pharmaceutical industry, where polysorbate-related particle formation is a pressing concern. By developing a practical, scalable solution for this complex analytical problem, Dr. Hoelterhoff has established herself as a key contributor to the advancement of robust biopharmaceutical manufacturing and quality assurance.
Research Focus
Key Achievements
Top Papers
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