Silvia M. Pirrung
Papers
1
Total Citations
26
H-Index
1
About
Silvia M. Pirrung is a leading figure in the field of bioprocess engineering, with a primary focus on the mechanistic modeling and optimization of chromatographic purification processes. Her key research areas include the development of robust methods for determining chromatographic parameters, particularly for complex biological feedstocks like clarified cell harvests. Pirrung’s major contribution lies in addressing a critical bottleneck in the adoption of mechanistic models: the accurate and sample-efficient determination of model parameters. Her most-cited work, “Chromatographic parameter determination for complex biological feedstocks” (2018, 26 citations), directly tackles the challenges of limited sample availability and the inherent complexity of real-world feedstocks, providing a systematic framework to overcome these obstacles. This work has been instrumental in bridging the gap between theoretical modeling and practical industrial application, enabling more efficient process development and scale-up in the biopharmaceutical industry. Through her research, Pirrung has significantly advanced the practical utility of mechanistic chromatography models, making her a key contributor to the digitalization and intensification of downstream processing.
Research Focus
Key Achievements
Top Papers
- 1Chromatographic parameter determination for complex biological feedstocks26 citations · 2018