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About
Shitij Kapur is a pioneering psychiatrist and neuroscientist whose work has fundamentally reshaped our understanding of schizophrenia and its treatment. His research centers on the neurobiology of psychosis, the mechanisms of antipsychotic drugs, and the critical role of dopamine dysregulation in mental illness. Kapur is best known for his groundbreaking "dopamine hypothesis of psychosis," which posits that aberrant salience—the misattribution of significance to irrelevant stimuli—is a core mechanism underlying psychotic symptoms. This framework has had a profound impact on both clinical practice and drug development, bridging the gap between molecular neuroscience and patient experience. His highly cited work, including a seminal paper on the role of dopamine in salience processing, has garnered tens of thousands of citations, cementing his status as one of the most influential figures in modern psychiatry. Kapur has also served as Dean of the Faculty of Medicine at the University of Melbourne and as Chief Executive of the South London and Maudsley NHS Foundation Trust, where he championed translational research and evidence-based mental health care. His contributions continue to guide researchers and clinicians in understanding and treating severe mental illness.
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