Shihong Qiu

Papers

Total Citations

114

H-Index

About

Shihong Qiu is a structural biologist and proteomics researcher whose work has made significant contributions to the field of high-throughput protein expression and structural genomics. Focused primarily on recombinant protein production for large-scale structural studies, Qiu has helped address one of the most persistent bottlenecks in biochemical and structural biology: the efficient expression of stable, soluble proteins from complex eukaryotic organisms. Qiu's most influential work, a 2004 study on high-throughput expression of *C. elegans* proteins (103 citations), established foundational methodologies for proteome-scale investigations using the nematode as a model organism, directly supporting both basic biological research and therapeutic development. Building on this, subsequent contributions in 2007 and 2008 refined these approaches by integrating improved domain selection strategies and cloning pipelines optimized for higher eukaryotic proteins — organisms notoriously difficult to work with at scale. Collectively, Qiu's research has helped accelerate the structural proteomics enterprise, enabling scientists worldwide to more efficiently determine protein folds and build public structural resources. His work represents an important technical foundation for researchers seeking to understand protein function across diverse biological systems.