Serenella Zambon
Papers
1
Total Citations
3
H-Index
1
About
Serenella Zambon is a distinguished researcher in pharmaceutical sciences, with a specialized focus on drug metabolism and cytochrome P450 (CYP) enzyme inhibition. Her major contribution lies in the development of a rapid, cost-effective assay for screening reversible CYP450 inhibition, uniquely capable of detecting both reversible inhibition and CYP3A4 metabolism-dependent inhibition (MDI) using recombinant proteins and fluorogenic substrates. This work, published in 2015, has garnered 3 citations, reflecting its niche but valuable impact on early-stage drug discovery and safety assessment. Zambon’s assay streamlines the identification of potential drug-drug interactions, offering a high-quality, efficient tool for pharmaceutical researchers. Her notable achievement includes advancing parallel screening methodologies that reduce time and cost without compromising accuracy, a critical step in preclinical development. By enabling simultaneous detection of multiple inhibition mechanisms, Zambon’s research supports safer drug design and enhances the predictive power of in vitro models. Her work is particularly relevant for students and researchers in pharmacology and toxicology, providing a practical framework for assessing CYP-mediated liabilities in new chemical entities.
Research Focus
Key Achievements
Top Papers
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