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About

Selwyn S. Jayakar is a leading researcher in stem cell biology and pain therapeutics, whose work focuses on the scalable generation of sensory neurons from human pluripotent stem cells (hPSCs). His major contribution lies in developing highly efficient, stepwise differentiation methods that mimic developmental biology principles to produce pseudo-unipolar sensory neurons—key cell types for studying pain mechanisms and testing non-addictive analgesics. His most-cited paper, "Scalable generation of sensory neurons from human pluripotent stem cells" (2023, 48 citations), demonstrates a breakthrough in creating reproducible, translational-ready cell models for drug discovery. A related 2022 study (4 citations) further refined these protocols, emphasizing peptidergic neuron subtypes critical for pain research. Jayakar’s work addresses a pressing need in the opioid crisis by enabling high-throughput screening of safer pain treatments. His achievements include advancing stem cell differentiation from a laboratory concept to a scalable platform, bridging developmental biology with clinical application. For students and researchers, Jayakar’s research exemplifies how stem cell technology can transform drug development, offering a robust toolkit to explore sensory neuron biology and accelerate the discovery of next-generation analgesics.