Sean E. Higinbotham

About

Sean E. Higinbotham is a leading researcher in orthopaedic biomechanics, specializing in the development and validation of subject-specific computational models of the human knee. His work directly addresses a critical gap in the field: the historical reliance on cadaveric data for model calibration, which limits clinical relevance. Higinbotham’s major contribution is pioneering the use of high-speed stereo radiography to capture *in vivo* knee kinematics, enabling the creation of digital twins that reflect living, dynamic joint behavior. His most-cited paper, "Apparatus for In Vivo Knee Laxity Assessment Using High-Speed Stereo Radiography" (2021, 14 citations), introduces the foundational technology for this approach. He has further demonstrated its application in total knee arthroplasty (TKA), showing how implant placement parameters influence post-operative varus-valgus angles (2025, 6 citations) and identifying determinants of pivot kinematics in posterior-stabilized TKA (2024, 5 citations). Through his validation studies (2024–2025), Higinbotham is establishing the rigorous calibration protocols necessary for translating subject-specific models from the lab to the clinic, promising more predictive tools for surgical planning and patient-specific outcomes.

Research Focus

Key Achievements

Top Papers

1. 1
   Apparatus for In Vivo Knee Laxity Assessment Using High-Speed Stereo Radiography

   14 citations · 2021
2. 2
   Implant placement parameters are associated with post operative dynamic varus and valgus knee angle in robotic assisted TKA

   6 citations · 2025
3. 3
   Determinants of pivot kinematics in posterior stabilized total knee arthroplasty

   5 citations · 2024
4. 4
   Validating subject-specific knee models from in vivo measurements

   3 citations · 2025
5. 5
   Validation of Subject-Specific Knee Models from In Vivo Measurements

   2 citations · 2024

Key Collaborators

Contact & Links