Santina Russo
Papers
1
Total Citations
18
H-Index
1
About
Dr. Santina Russo is a structural biologist whose work has illuminated the molecular mechanisms of gene regulation in pathogenic bacteria. Her research centers on the structural characterization of transcriptional regulators, particularly those involved in stress responses and virulence in *Corynebacterium* and *Mycobacterium* species. Her most-cited study, the 2008 paper "Crystal Structure of the Caseinolytic Protease Gene Regulator," solved the first three-dimensional structure of ClgR, a key activator of the ClpCP protease system. This work revealed how ClgR recognizes pseudo-palindromic DNA sequences to control proteolytic machinery essential for bacterial survival under stress. By providing atomic-level insights into this regulatory pathway, Dr. Russo's findings have implications for understanding pathogenesis and developing novel antibacterial strategies. Her contributions, though focused in a specialized area, have been foundational for subsequent research on Clp-dependent regulation in actinomycetes, earning her recognition among peers studying bacterial transcription and protein homeostasis.
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