Rebecca Feltham
Papers
1
Total Citations
168
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1
About
Rebecca Feltham is a structural biologist whose research centers on the molecular mechanisms of cell death and survival, particularly through the lens of ubiquitin signaling and inhibitor of apoptosis (IAP) proteins. Her major contributions include elucidating the conformational dynamics of the cIAP2 RING domain, a pivotal region that recruits ubiquitin-conjugating enzymes (E2s) to drive ubiquitylation and degradation of IAPs. This work, published in her highly cited 2008 paper (168 citations), revealed how structural changes in the RING domain facilitate E2 binding, a process critical for triggering cell death when IAP antagonists are used in cancer therapy. By providing atomic-level insights into these interactions, Feltham’s research has advanced our understanding of how to exploit IAP vulnerabilities in tumors, where these proteins are often overexpressed. Her findings have implications for designing more effective pro-apoptotic drugs, making her a key figure in the intersection of structural biology and oncology.
Research Focus
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