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About

Raissa Mathura is a leading researcher at the intersection of neurosurgery, neuroimaging, and psychiatric neuromodulation. Her work centers on understanding the circuit-level pathophysiology of treatment-resistant psychiatric disorders, particularly depression, and translating these insights into targeted surgical interventions. A key contribution is her pioneering use of stereo-electroencephalography (SEEG) to map and guide network modulation for conditions like treatment-resistant depression (TRD). Her 2023 paper on SEEG-guided network modulation for psychiatric disorders—already garnering 10 citations—lays critical groundwork for refining deep brain stimulation (DBS) by identifying patient-specific epileptogenic and pathological networks. Mathura’s research bridges the gap between invasive electrophysiology and clinical psychiatry, offering a precision-medicine approach to neuromodulation. Her work has significant implications for surgical planning and patient selection, helping to move DBS from a one-size-fits-all paradigm toward individually tailored circuit-based therapies. By combining rigorous surgical considerations with advanced neuroimaging, Mathura is shaping the future of psychiatric neurosurgery, making her a vital voice for students and clinicians interested in the next frontier of brain stimulation.