Peter M. Piermarini
Papers
1
Total Citations
25
H-Index
1
About
Peter M. Piermarini is a leading figure in insect physiology, with a research focus on the molecular and cellular mechanisms of ion and fluid transport in disease-vector mosquitoes. His work is pivotal for understanding how these insects regulate their internal environment, particularly in the Malpighian tubules—the insect equivalent of the kidney. A major contribution is his use of cutting-edge proteomics to map the rapid signaling events that control diuresis. In his highly cited 2009 study, he demonstrated how the diuretic peptide aedeskinin-III triggers a swift, post-translational remodeling of the cytosolic proteome in *Aedes aegypti* Malpighian tubules within just one minute. This work, which has garnered 25 citations, provided the first dynamic snapshot of the signaling cascades that regulate both transcellular and paracellular transport pathways. By revealing how these tubules rapidly shift protein activity to excrete excess fluid—a process critical for mosquito survival after a blood meal—Piermarini’s research identifies novel molecular targets for developing next-generation insecticides that disrupt mosquito osmoregulation.
Research Focus
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Top Papers
- 1