Peter J. Skene
Papers
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Total Citations
2
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About
Peter J. Skene is a trailblazer in epigenomics and molecular biology, best known for co-developing the revolutionary CUT&RUN (Cleavage Under Targets and Release Using Nuclease) technique. This method enables high-resolution, genome-wide profiling of protein-DNA interactions from as few as a single cell, dramatically reducing the cost, time, and cell requirements compared to traditional ChIP-seq. Skene’s work has transformed how researchers map transcription factor binding, histone modifications, and chromatin states, making epigenomic studies accessible for rare cell populations and clinical samples. His contributions have garnered widespread adoption, with CUT&RUN protocols cited extensively across the field. Beyond this flagship innovation, Skene has advanced understanding of chromatin biology and gene regulation, publishing influential papers that bridge technology development and fundamental discovery. His achievements include pioneering low-input epigenomic assays that have opened new frontiers in developmental biology, neuroscience, and cancer research. For students and researchers, Skene exemplifies how a single methodological breakthrough can empower an entire field, enabling deeper insights into the molecular mechanisms of gene expression and cellular identity.
Research Focus
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Top Papers
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