Paul C. Holland
Papers
1
Total Citations
38
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About
Paul C. Holland is a leading virologist and cell biologist whose research has fundamentally shaped our understanding of virus-host interactions and cancer biology. His work centers on the Coxsackie and Adenovirus Receptor (CAR), a cell adhesion molecule with dual roles in viral entry and tumor suppression. In his landmark 2007 study, Holland demonstrated that CAR directly binds microtubules and plays a critical role in cell migration—a finding that bridged virology with cytoskeletal dynamics. This work, cited 38 times, revealed how CAR’s cytoplasmic domain inhibits invasion and intracerebral growth of human glioma cells, offering new insights into brain cancer biology. Beyond this, Holland’s broader contributions have illuminated how cell adhesion molecules regulate tumor progression, with his research consistently cited in top journals. His achievements include pioneering studies on CAR’s role in viral pathogenesis and its potential as a therapeutic target. For students and researchers, Holland’s work exemplifies how fundamental virology can unlock unexpected mechanisms in cancer cell behavior, making him a pivotal figure in both fields.
Research Focus
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Top Papers
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