Patrick Umbach
Papers
1
Total Citations
99
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1
About
Patrick Umbach is a structural biologist whose work has been instrumental in advancing high-throughput protein crystallography, particularly for human proteins. His research centers on the development and application of methods for large-scale structural analysis, a cornerstone of the structural genomics movement. Umbach’s most notable contribution, detailed in his highly cited 2003 paper (99 citations), describes the facilities and methodologies established by the Protein Structure Factory in the Berlin area. This work outlines a systematic pipeline for expressing human protein genes in recombinant *E. coli* or yeast, enabling the rapid crystal structure determination of targets that are often challenging to produce. By tackling the bottleneck of protein expression and crystallization, Umbach’s efforts have helped lay the groundwork for modern, high-throughput structural biology pipelines. His contributions are particularly significant for the field of human proteomics, where understanding protein structures at scale is critical for drug discovery and disease research. Through this work, Umbach has demonstrated how engineering and methodological innovation can accelerate the pace of fundamental biological discovery.
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