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1
Total Citations
47
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About
Olsen As is a pioneer in the automation of genomic library construction, whose work has fundamentally shaped high-throughput genomics. His key research areas include robotic laboratory automation, genomic library arraying, and the development of tools for physical mapping. His most notable contribution is the development of an automated system for producing high-density colony filters of cosmid and YAC libraries, detailed in his 1993 paper (47 citations). This work introduced the high-density replicating system (HDR) for the Beckman Biomek 1000 robotic workstation, featuring a 96-pin tool, sterilization station, and custom control software. By enabling the rapid, reproducible transfer of thousands of clones onto filters, his innovation dramatically accelerated the screening and mapping of large-insert genomic libraries during the early genomics era. This foundational technology supported major genome projects and remains a benchmark in laboratory robotics. Olsen As’s achievements exemplify how engineering solutions can transform biological discovery, making him a key figure in the history of automated genomics.
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