Natalie Rahmen
Papers
1
Total Citations
65
H-Index
1
About
Natalie Rahmen is a biochemical engineer whose research focuses on optimizing microbial production systems, particularly through high-throughput experimentation and process engineering. Her key contributions lie in enhancing the productivity of *E. coli* expression systems, with a special emphasis on the T7-based platform widely used in recombinant protein production. Her most cited work, "Utilizing high-throughput experimentation to enhance specific productivity of an *E. coli* T7 expression system by phosphate limitation" (2011, 65 citations), demonstrates a novel approach: rather than relying solely on genetic modifications, she showed that strategic nutrient limitation—specifically phosphate—can redirect cellular resources from biomass growth toward protein synthesis. This work, leveraging parallel mini-bioreactor systems, offers a scalable, cost-effective strategy for industrial bioprocessing. Rahmen’s research bridges the gap between strain engineering and process optimization, providing practical tools for improving yield in therapeutic protein manufacturing. Her findings are particularly valuable for researchers working on fed-batch cultures and metabolic burden reduction. By integrating high-throughput methods with classical biochemical engineering, she has contributed a powerful, data-driven framework for accelerating bioprocess development.
Research Focus
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Top Papers
- 1