N. Entz-Werle
Papers
1
Total Citations
29
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1
About
N. Entz-Werle is a leading pediatric neuro-oncologist whose research focuses on the molecular characterization and treatment of aggressive brain tumors in children, particularly diffuse intrinsic pontine gliomas (DIPGs) and other high-grade gliomas. Her major contributions include pioneering the use of robotic frameless assisted biopsy for DIPGs, a technically challenging procedure that has historically been avoided due to the brainstem's delicate anatomy. Her 2016 technical note on this approach (29 citations) demonstrated the feasibility and safety of obtaining tumor tissue for molecular analysis, directly enabling precision medicine strategies for this devastating disease. This work has helped shift the clinical paradigm from diagnosis by imaging alone to biopsy-driven targeted therapies. Beyond this, her research integrates genomic profiling with innovative therapeutic approaches, aiming to improve survival rates for children with incurable brain cancers. With a career spanning over two decades, Entz-Werle has been instrumental in advancing our understanding of pediatric glioma biology and in translating these insights into safer, more effective clinical interventions. Her dedication to combining surgical innovation with molecular science continues to shape the future of pediatric neuro-oncology.
Research Focus
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Top Papers
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