Miguel Ruiz-de la Cruz

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About

Miguel Ruiz-de la Cruz is a leading researcher in oral microbiology, with a primary focus on the role of fungal pathogens in periodontal disease. His work has significantly advanced our understanding of *Candida albicans* as a secondary colonizer in periodontal infections, challenging traditional views of bacterial dominance in these conditions. In his landmark 2025 study, Ruiz-de la Cruz analyzed 268 patient samples to map the expression patterns of ALS (adhesion) and SAP (protease) gene families in *C. albicans* strains isolated from periodontal disease patients versus healthy controls. This research revealed distinct gene clusters that correlate with disease severity, providing critical insights into fungal virulence mechanisms in the oral microbiome. With 3 citations already, this work is gaining traction as a foundational reference in the emerging field of fungal-bacterial interactions in periodontitis. His contributions are shaping new diagnostic and therapeutic strategies for managing periodontal infections, making him a rising authority in oral health research.