Mario Leutert
Papers
2
Total Citations
222
H-Index
2
About
Mario Leutert is a proteomics researcher whose work sits at the intersection of mass spectrometry, cell signaling, and laboratory automation. He has made significant contributions to the field of phosphoproteomics — the large-scale study of protein phosphorylation, a critical mechanism by which cells regulate signaling networks. His most cited work, "R2-P2 rapid-robotic phosphoproteomics" (2019, 204 citations), introduced a groundbreaking automated pipeline that dramatically improved the throughput, reproducibility, and robustness of phosphoproteomic analyses, enabling researchers to routinely identify and quantify over 10,000 phosphorylation sites across complex multi-perturbation experiments. This advance addressed longstanding bottlenecks that had limited the scale and reliability of signaling studies. Building on this foundation, Leutert continued pushing methodological boundaries with his 2023 work on automated phosphotyrosine peptide enrichment, tackling the high cost and reproducibility challenges associated with studying this particularly important — yet technically demanding — class of signaling modifications. Together, his contributions have helped democratize large-scale phosphoproteomics, equipping the broader research community with more accessible and powerful tools to decode the molecular logic of cellular signaling in both fundamental biology and disease contexts.
Research Focus
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Top Papers
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