Mariko Nagaje

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About

Mariko Nagaje is a pioneering neurosurgeon whose work has fundamentally shaped the landscape of stereotactic radiosurgery. Her primary research focuses on the clinical application and technological refinement of Gamma Knife surgery, particularly for complex cranial and spinal pathologies. Dr. Nagaje’s most significant contribution is her instrumental role in the clinical introduction and validation of the Leksell Gamma Knife Perfexion, the world’s first fully robotic radiosurgery system. Her landmark 2009 paper, cited over 90 times, provided the first rigorous evaluation of this revolutionary technology, demonstrating its enhanced precision, efficiency, and safety for treating head and neck lesions. This work established the Perfexion as a new gold standard, dramatically expanding the treatable patient population and reducing treatment times. Beyond this seminal study, her research has systematically explored dose planning optimization and long-term outcomes for conditions ranging from arteriovenous malformations to trigeminal neuralgia. Dr. Nagaje’s blend of surgical insight and engineering collaboration has not only advanced a specific device but has also set the benchmark for how next-generation radiosurgical platforms are developed and implemented globally, making her a central figure in modern, non-invasive neurosurgery.